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Number of patent applications to the EPO (Per million of inhabitants)
| 2000 | 2005 | 2010 | 2011 | 2012 |
| Baden-Württemberg | 499,01 | 584,66 | 524,93 | 513,12 | 388,86 |
| Bayern | 440,38 | 437,27 | 452,09 | 434,82 | 367,68 |
| Bremen | 71,82 | 101,40 | 98,12 | 106,80 | 85,08 |
| Hamburg | 186,05 | 225,17 | 188,03 | 240,99 | 201,07 |
| Niedersachsen | 172,62 | 180,48 | 180,02 | 185,24 | 150,55 |
| Mecklenburg-Vorpommern | 34,51 | 38,65 | 59,64 | 47,13 | 39,27 |
| Hessen | 331,20 | 322,76 | 286,62 | 299,64 | 217,94 |
| Saarland | 126,18 | 157,17 | 159,08 | 147,09 | 134,17 |
| Sachsen-Anhalt | 42,37 | 45,73 | 43,47 | 41,93 | 35,13 |
| Berlin | 174,43 | 205,50 | 205,96 | 198,15 | 164,35 |
| Brandenburg | 64,20 | 99,52 | 106,07 | 97,71 | 88,27 |
| Nordrhein-Westfalen | 251,54 | 257,82 | 260,75 | 244,38 | 205,48 |
| Rheinland-Pfalz | 280,83 | 320,92 | 276,36 | 276,67 | 206,30 |
| Thüringen | 86,00 | 112,98 | 123,72 | 120,94 | 115,77 |
| Sachsen | 91,63 | 96,95 | 119,87 | 106,60 | 90,73 |
| Schleswig-Holstein | 131,89 | 142,32 | 148,28 | 175,86 | 147,10 |