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Number of patent applications (number)
| 1990 | 2000 | 2005 | 2010 | 2011 | 2012 |
| Lombardy | 795,91 | 1 378,37 | 1 458,42 | 1 292,98 | 1 214,65 | 909,08 |
| Piedmont | 328,80 | 436,41 | 629,93 | 486,59 | 513,52 | 402,21 |
| Liguria | 41,80 | 92,21 | 84,89 | 129,24 | 105,27 | 90,04 |
| Campania | 18,59 | 47,81 | 100,96 | 73,29 | 59,13 | 56,15 |
| Apulia | 14,17 | 34,96 | 54,62 | 57,44 | 66,30 | 38,65 |
| Abruzzo | 15,28 | 66,88 | 49,75 | 46,17 | 51,21 | 25,58 |
| Sicily | 27,83 | 61,71 | 81,71 | 49,75 | 29,74 | 21,89 |
| Calabria | 3,33 | 7,90 | 17,40 | 10,95 | 11,64 | 17,95 |
| Sardinia | 6,25 | 12,95 | 17,77 | 18,66 | 12,79 | 9,34 |
| Aosta Valley | 3,17 | 9,17 | 10,03 | 6,25 | 3,54 | 6,52 |
| Basilicata | | 2,43 | 7,01 | 5,18 | 5,70 | 5,95 |
| Molise | 0,60 | 1,50 | 3,58 | 1,74 | 2,83 | 0,92 |