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Number dying between 0-64 years (number)
| 1990 | 2000 | 2005 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 |
| Campania | 1 424 | 1 136 | 1 013 | 982 | 919 | 873 | 861 | 816 | 842 | 806 |
| Aosta Valley | 1 392 | 827 | 732 | 320 | 924 | 553 | 815 | 1 113 | 983 | 774 |
| Sardinia | 1 035 | 894 | 865 | 641 | 760 | 618 | 665 | 663 | 771 | 703 |
| Molise | 920 | 901 | 637 | 756 | 354 | 880 | 775 | 568 | 799 | 685 |
| Sicily | 1 197 | 968 | 758 | 781 | 763 | 849 | 815 | 747 | 829 | 680 |
| Calabria | 1 112 | 966 | 797 | 765 | 712 | 731 | 653 | 689 | 774 | 678 |
| Piedmont | 1 197 | 964 | 858 | 734 | 765 | 749 | 702 | 694 | 758 | 675 |
| Apulia | 1 110 | 802 | 779 | 703 | 756 | 687 | 683 | 645 | 666 | 656 |
| Lombardy | 1 333 | 985 | 802 | 721 | 699 | 700 | 705 | 644 | 716 | 643 |
| Basilicata | 1 281 | 1 011 | 971 | 932 | 878 | 678 | 764 | 774 | 604 | 631 |
| Liguria | 1 125 | 963 | 828 | 768 | 832 | 733 | 758 | 693 | 706 | 630 |
| Abruzzo | 975 | 795 | 702 | 640 | 755 | 650 | 689 | 665 | 619 | 559 |